The authors of a current evaluation investigated what is understood about gut microbiota in centenarians and how gut microbes can help people achieve extreme longevity [1].
What makes centenarians particular?
A method of investigating what provides individuals longevity and well being in older ages is to check individuals who have achieved it, particularly those that have lived for 100 years: centenarians.
It’s not but utterly understood how centenarians differ from individuals who have been unable to reside so lengthy. Many elements, together with life-style elements and genetics, can impression whether or not an individual can reside to previous age in good well being, however there’s nonetheless not sufficient understanding of what makes centenarians so particular.
The authors of this evaluation appeared into a possible issue with an amazing impression on metabolism and well being: intestine microbiota, the microbes that reside within the human intestine. They collected scientific proof concerning these microbioes’ impression “as a possible protecting issue for attaining excessive longevity.”
Irritation and microbiota
Inflammaging, the low-grade persistent irritation that accompanies ageing, and its destructive impression on well being are broadly recognized. Inflammaging additionally disrupts intestine microbes. This evaluation’s authors clarify that such persistent irritation creates situations wherein sure species of microbes related to higher well being have problem rising and reproducing. Concurrently, these situations are favorable to microbes related to unhealthy ageing, that are often called pathobionts. Subsequently, finding out centenarians’ microbiota might help to reply questions on how inflammaging-protective mechanisms can develop.
Centenarians’ microbial composition
The composition of microbiota modifications with age. Some microbes are misplaced and changed by new microbes, which might contain potential pathobionts. This transition is a doable goal for interventions.
Analysis executed within the Blue Zones, geographical areas with a excessive fee of long-lived populations, demonstrated that people residing there have intestine microbiomes enriched in microbes which might be thought of helpful and are linked to more healthy physique mass index, immunomodulation, and homeostasis [2, 3].
The authors additionally gathered proof from a number of research that checked out how centenarians’ microbiota differ from non-centenarians’. They famous that the microbes that have been elevated within the centenarians have been related to safety in opposition to inflammatory bowel illness, metabolic syndromes, weight problems, and diabetes [4] together with prevention of colitis [5], liver illness [6], psychiatric problems [7], and anxiousness and depressive problems [8]. Moreover, they possess an antitumor impact [9].
Alternatively, microbes whose ranges are decreased within the centenarians possess “antioxidant and anti inflammatory results,” and decreased ranges of one of many teams “is related to inflammatory bowel illnesses, irritable bowel syndrome, weight problems, liver problems, metabolic situations, most cancers, neurological situations, and dermatitis” [10].
Microbial metabolites and longevity
Modifications in microbiota composition are associated to modifications in metabolites produced by microbes. These have additionally been investigated. A research on Italian centenarians revealed modifications within the modifications of some lipid teams. Researchers additionally noticed “decreased circulating ranges of lipid peroxidation markers,” that’s, decreased lipid deterioration by reactive oxygen species [11].
Alternatively, analysis additionally recognized that some metabolites produced by microbiota is usually a marker of shorter life expectancy. For instance, proof from cohorts in the US reveals that the presence of metabolic merchandise of citric acid and bile acid metabolism is related to a decrease chance of reaching the age of 80 [12]. Nevertheless, there’s contradictory proof from cohorts situated in Bama, China, which is likely one of the Blue Zones. Centenarians from that cohort have excessive fecal short-chain fatty acids and whole bile acids [13]. Untangling these seemingly contradictory outcomes would require additional investigation.
The necessity to broaden analysis
The authors level that there’s nonetheless very restricted proof concerning centenarians’ microbiota, which isn’t stunning given the range of the microorganisms within the human intestine, “which might range primarily based on geographic location, life, treatment, or related illnesses.” Gaining extra stable information on this space can result in the identification of therapeutic targets, enable for designing interventions to alter the composition of microbes, or function a biomarker.
The authors recommend that future research ought to examine in additional depth how microbial composition evolves by means of life and the way it impacts the lifespan of a person. Primarily based on earlier information on this topic, they recommend that such variables as “mode of delivery, sort, and high quality of postnatal breastfeeding, environmental publicity, and hygienic situations” and their position within the connection between intestine microbes, longevity, and wholesome ageing ought to be investigated.
Literature
[1] Lozada-Martinez, I. D., Lozada-Martinez, L. M., & Anaya, J. M. (2024). Intestine microbiota in centenarians: A possible metabolic and ageing regulator within the research of maximum longevity. Getting older medication (Milton (N.S.W)), 7(3), 406–413.
[2] Wang, F., Yu, T., Huang, G., Cai, D., Liang, X., Su, H., Zhu, Z., Li, D., Yang, Y., Shen, P., Mao, R., Yu, L., Zhao, M., & Li, Q. (2015). Intestine Microbiota Neighborhood and Its Meeting Related to Age and Weight loss plan in Chinese language Centenarians. Journal of microbiology and biotechnology, 25(8), 1195–1204.
[3] Kong, F., Hua, Y., Zeng, B., Ning, R., Li, Y., & Zhao, J. (2016). Intestine microbiota signatures of longevity. Present biology : CB, 26(18), R832–R833.
[4] Rodrigues, V. F., Elias-Oliveira, J., Pereira, Í. S., Pereira, J. A., Barbosa, S. C., Machado, M. S. G., & Carlos, D. (2022). Akkermansia muciniphila and Intestine Immune System: A Good Friendship That Attenuates Inflammatory Bowel Illness, Weight problems, and Diabetes. Frontiers in immunology, 13, 934695.
[5] Jia, D. J., Wang, Q. W., Hu, Y. Y., He, J. M., Ge, Q. W., Qi, Y. D., Chen, L. Y., Zhang, Y., Fan, L. N., Lin, Y. F., Solar, Y., Jiang, Y., Wang, L., Fang, Y. F., He, H. Q., Pi, X. E., Liu, W., Chen, S. J., & Wang, L. J. (2022). Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesIL-10 activation. Intestine microbes, 14(1), 2145843.
[6] Zhao, Y., Li, C., Luan, Z., Chen, J., Wang, C., Jing, Y., Qi, S., Zhao, Z., Zhang, H., Wu, J., Chen, Y., Li, Z., Zhao, B., Wang, S., Yang, Y., & Solar, G. (2023). Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous ldl cholesterol biosynthesis. Scientific experiences, 13(1), 12946.
[7] Yun, S., Park, H., Shin, Y., Ma, X., Han, M. J., & Kim, D. (2023). Lactobacillus gasseri NK109 and Its Complement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Intestine Microbiota Composition. Vitamins, 15(3), 790.
[8] Duranti, S., Ruiz, L., Lugli, G. A., Tames, H., Milani, C., Mancabelli, L., Mancino, W., Longhi, G., Carnevali, L., Sgoifo, A., Margolles, A., Ventura, M., Ruas-Madiedo, P., & Turroni, F. (2020). Bifidobacterium adolescentis as a key member of the human intestine microbiota within the manufacturing of GABA. Scientific Reviews, 10(1).
[9] Wu, L., Xie, X., Li, Y., Liang, T., Zhong, H., Yang, L., Xi, Y., Zhang, J., Ding, Y., & Wu, Q. (2022). Intestine microbiota as an antioxidant system in centenarians related to excessive antioxidant actions of gut-resident Lactobacillus. NPJ biofilms and microbiomes, 8(1), 102.
[10] Martín, R., Rios-Covian, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez-Humarán, L. G., Sokol, H., Chatel, J. M., & Langella, P. (2023). Faecalibacterium: a bacterial genus with promising human well being purposes. FEMS microbiology opinions, 47(4), fuad039.
[11] Collino, S., Montoliu, I., Martin, F. P., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., Brigidi, P., Franceschi, C., & Rezzi, S. (2013). Metabolic signatures of maximum longevity in northern Italian centenarians reveal a fancy reworking of lipids, amino acids, and intestine microbiota metabolism. PloS one, 8(3), e56564.
[12] Montoliu, I., Scherer, M., Beguelin, F., DaSilva, L., Mari, D., Salvioli, S., Martin, F. P., Capri, M., Bucci, L., Ostan, R., Garagnani, P., Monti, D., Biagi, E., Brigidi, P., Kussmann, M., Rezzi, S., Franceschi, C., & Collino, S. (2014). Serum profiling of wholesome ageing identifies phospho- and sphingolipid species as markers of human longevity. Getting older, 6(1), 9–25.
[13] Cheng, S., Larson, M. G., McCabe, E. L., Murabito, J. M., Rhee, E. P., Ho, J. E., Jacques, P. F., Ghorbani, A., Magnusson, M., Souza, A. L., Deik, A. A., Pierce, Ok. A., Bullock, Ok., O’Donnell, C. J., Melander, O., Clish, C. B., Vasan, R. S., Gerszten, R. E., & Wang, T. J. (2015). Distinct metabolomic signatures are related to longevity in people. Nature communications, 6, 6791.
